iLABPharma Poland – Aromasin (Exemesaten) 12.5mg x 50 QTY

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Aromasin, an aromatase inhibitor (AI), is part of a broader class of drugs known as anti-estrogens, which also includes selective estrogen receptor modulators (SERMs) like Nolvadex and Clomid. These two subcategories — AIs and SERMs — each play distinct roles in estrogen control, particularly relevant in the context of bodybuilding and anabolic steroid use.

There has been a longstanding misunderstanding within the anabolic steroid and bodybuilding community about how SERMs operate. Contrary to the common belief, SERMs such as Nolvadex and Clomid do not lower estrogen levels in the body. Instead, they function by blocking estrogen’s effects in specific tissues. For example, SERMs block estrogen at receptor sites in breast tissue, preventing estrogen from exerting its effects there. However, they can mimic estrogen effects in other tissues, such as the liver in the case of Nolvadex. This selective mechanism does not reduce circulating estrogen levels but blocks its activity where it might cause adverse effects.

In contrast, AIs like Aromasin directly reduce estrogen levels by targeting and inhibiting the aromatase enzyme, responsible for converting androgens into estrogen. Aromasin is a potent steroidal AI known as a suicidal aromatase inhibitor, which means it permanently binds to and deactivates the aromatase enzyme it attaches to. This action leads to a significant reduction in estrogen production, with research showing Aromasin can decrease estrogen levels by up to 85% in breast cancer patients.

The key advantage of Aromasin over other non-suicidal AIs, such as Arimidex and Letrozole, is that it permanently inhibits the bound aromatase enzymes. This irreversible binding prevents any chance of estrogen rebound, which can occur when non-suicidal AIs are discontinued and the temporarily inhibited enzymes start functioning again, potentially leading to a rapid increase in estrogen production.

This unique property of Aromasin makes it a critical tool in managing estrogen levels effectively, especially important for athletes managing side effects during and after cycles of anabolic steroids.