APO – ARIMIDEX ANASTROZOLE 1MG [30 TABS]

Description

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Arimidex, with its active ingredient Anastrozole, is an anti-estrogenic medication primarily developed to treat advanced breast cancer in postmenopausal women. As a leading drug in the class of third-generation selective oral aromatase inhibitors, it works by inhibiting the enzyme aromatase, thereby reducing estrogen production in the body. This mechanism is crucial since many breast cancer cells grow in response to estrogen. Unlike tamoxifen citrate (Nolvadex®), which blocks estrogen at its receptor, Arimidex reduces the hormone’s endogenous production. With its potent effects, a daily dose of 1 mg can suppress estrogen levels by over 80% in treated patients.

History of Arimidex

Developed by Zeneca Pharmaceuticals and approved in the United States in 1995, Arimidex was introduced as a novel treatment for operable breast cancer in postmenopausal women, challenging the longstanding use of tamoxifen. Following its introduction, Arimidex was the focus of the ATAC trial (Arimidex, Tamoxifen, Alone or in Combination), a large multicenter double-blind study conducted in Rome. This study, which examined the effects of Arimidex and tamoxifen, alone or combined, in 9,366 postmenopausal women post-surgery, showed Arimidex to be superior in promoting disease regression and improving survival rates. Since its publication in 2002, Arimidex has become a favored option in this therapeutic area. Additionally, its strong estrogen suppression capabilities have made it popular among male bodybuilders and athletes for managing side effects associated with elevated estrogen levels from anabolic/androgenic steroid use.

How Arimidex is Supplied

Arimidex is typically available in 1mg tablets.

Structural Characteristics

Anastrozole is a selective non-steroidal aromatase inhibitor, chemically described as 1,3-benzenediacetonitrile, a,a,a’,a’-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl).

Potential Side Effects

Common side effects from Arimidex include hot flashes, joint pain, weakness, fatigue, mood changes, depression, high blood pressure, limb swelling, and headaches. It may also decrease bone mineral density, leading to osteoporosis and increased fracture risk. Gastrointestinal issues such as nausea and vomiting can occur. Notably, aromatase inhibitors can be detrimental to fetal development and should never be used or handled during pregnancy. In men, off-label use to counteract steroid-induced estrogenicity might increase cardiovascular disease risk due to significant HDL cholesterol suppression, especially when used with aromatizable steroids like testosterone enanthate.

Administration Guidelines

For postmenopausal women with hormone receptor-positive early breast cancer, locally advanced metastatic breast cancer, or those experiencing disease progression following tamoxifen therapy, the recommended dosage of Arimidex is 1mg per day until disease progression halts. In bodybuilding and athletic contexts, men often use 0.5 mg to 1 mg per day to control estrogen-related side effects. Sometimes, half a tablet (0.5 mg) every other day suffices, especially when used with steroids prone to aromatization, such as methandrostenolone or testosterone, to prevent gynecomastia and water retention. Arimidex can also reduce fat mass and sharpen muscle definition, making it useful for cutting phases. Food does not affect Arimidex absorption, so it can be taken with or between meals.